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Postural orthostatic tachycardia syndrome

postural orthostatic tachycardia syndrome

Abstract

Postural orthostatic tachycardia syndrome (POTS) is an autonomic disturbance which has become better understood in recent years. It is now thought to encompass a group of disorders that have similar clinical features, such as orthostatic intolerance, but individual distinguishing parameters—for example, blood pressure and pulse rate. The clinical picture, diagnosis, and management of POTS are discussed.

Postural orthostatic tachycardia syndrome (POTS) is an autonomic disturbance characterized by the clinical symptoms of orthostatic intolerance, mainly lightheadedness, fatigue, sweating, tremor, anxiety, palpitation, exercise intolerance and near syncope on upright posture. These are relieved on lying down. Patients also have a heart rate >120 beats/min (bpm) on standing or increase their heart rate by 30 bpm from a resting heart rate after standing for 10 min. The symptoms lead to the limitation of activities impacting on a patient's life on a daytoday basis—for example, bathing, housework, feeding. The severity of symptoms is more pronounced compared to a condition like pure autonomic failure. Patients with POTS may not have blood pressure changes and can have fluctuation of blood pressure in either direction. Other conditions like chronic debilitating disorders, prolonged bed rest or medication that impair autonomic function have to be excluded.

HISTORY AND EPIDEMIOLOGY

POTS was first described 1940. Low et al from the Mayo clinic did the pioneering work on this condition.3 Robertson of the Vanderbilt autonomic laboratories stated it was one of the most common conditions in young females. Frolich et al reported patients who developed symptomatic postural tachycardia without any change in blood pressure.

The condition is common in the age group 12–50 years with a female to male ratio of 5:1. It is common after stress such as sepsis, pregnancy, fever, surgery or trauma. In some of the variants of POTS there is a functional mutation in the gene encoding for norepinephrine (noradrenaline) transportation. Ala 457pro mutation renders the transfers nonfunctional leading to altered heart rate as well as epinephrine (adrenaline) metabolites.

PATHOGENESIS

Several theories have been suggested for the aetiopathogenesis of POTS. Suggested factors that may lead to POTS include impaired vascular innervation, high plasma norepinephrine concentrations, αreceptor sensitivity, βreceptor hypersensitivity and baroreceptor dysfunction.

Impaired innervation of the veins or their response to sympathetic stimulation plays a key role in the aetiopathogenesis of POTS. This leads to dependent venous pooling in the legs and reduced venous return to the heart. Thus there is redistribution of blood in the peripheral circulation. This could be worsened by capillary leakage, which leads to further hypovolaemia and causes reflex tachycardia. There is sympathetic cardiac activity without vasoconstriction, inducing a fall in central venous pressure. When this process continues, circulatory collapse may occur.

TYPES/VARIANTS

POTS can be classified as primary and secondary (box 1). Partial dysautonomia can be caused by various stresses and has an immune mediated pathogenesis. Serum autoantibodies to α3 acetylcholine receptors of the peripheral ganglia have been found. The partial dysautonomic form can also affect adolescents. Symptoms initially worsen until the patient reaches 16 years of age and then gradually fade away. This is thought to be due to autonomic imbalance.

In some primary cases there is an hyperadrenergic state leading to increased norepinephrine, which could be due to impaired clearance or decreased uptake by the synaptic cleft. These variants cause profuse sweating, anxiety and tremulousness and the diastolic pressure is high. This is thought to be a genetic disorder with involvement of family members. In these patients symptoms will be gradual and progressive. They will have orthostatic tachycardia as well as associated hypertension.

Evaluation

A detailed history of orthostatic intolerance (box 2), and specific findings on physical examination (box 3) and investigations (box 4), will give clues to the diagnosis.

Catecholamines should be measured in serum as well as in 24 h urine. In some variants of POTS there is a high concentration of catecholamines in blood as well as urine, and a high concentration of their metabolites like dihydroxyphenylglycol in urine. There is impaired response to tyramine with reduced clearance of norepinephrine at the synaptic cleft. Sweat test as well as skin resistance can assess sudomotor function.

Box 1 Classification of postural tachycardia syndrome

Primary forms

  • Partial dysautonomic
  • Immune mediated pathogenesis
  • Adolescence
  • Hyperadrenergic state

Secondary forms

  • Diabetes mellitus
  • Amyloidosis
  • Heavy metal poisoning
  • Sjogren syndrome
  • Hypermobility syndrome
  • Paraneoplastic syndrome

The 70° head up tilt table study has become the standard stress test for orthostatic integrity and thus of neurovascular competence. Patterns of heart rate as well as blood pressure response will be the key to identifying which type of orthostatic intolerance is present and thus for planning treatment for further management. In a control population there is an increase of only 15 bpm in heart rate in the first minute of standing and a further increase for 9 min. In POTS supine heart rate is greater than the normal control population and an increase of more than 30 bpm takes place between 1–5 min on 70° head uplift.

DIFFERENTIAL DIAGNOSIS

Inappropriate sinus tachycardia syndrome

This is a clinical condition in which the heart rate increases out of proportion to physical needs. The automaticity of the sinus node is increased with increased cardiac sympathetic tone and blunted cardiac parasympathetic tone. Most of the features are similar to POTS, but in inappropriate sinus tachycardia syndrome, unlike POTS, the heart rate never exceeds 100 bpm in the supine position and increases on standing.

Chronic fatigue syndrome

In Europe, chronic fatigue syndrome (CFS) is called myalgic encephalomyelitis (ME). Orthostatic intolerance is a broad title for blood pressure abnormalities such as neurally mediated hypotension (NMH) and POTS. Orthostatic intolerance is a symptom of CFS. CFS is a chronic condition associated with high morbidity. The US Centers for Disease Control and Prevention (CDC) criteria for the diagnosis of CFS include chronic debilitating fatigue lasting for 6 months or more, associated cognitive difficulties, pharyngitis, muscle pain, joint pain, headache, sleep disturbance and postexercise malaise that is unexplained by other illness.

Patients with CFS have findings similar to the findings in patients with POTS during the head up tilt table test. Patients with POTS may also have fatigue as a prominent clinical feature. Orthostatic tachycardia and autonomic abnormalities are present in both conditions, which is qualitatively difficult to differentiate. The heart rate variability and blood pressure variation is similar in both conditions. POTS fails to satisfy CDC criteria for CFS.

TREATMENT

Drugs to avoid

Review all the drugs which the patient is taking. Drugs which can aggravate the symptoms of POTS are angiotensinconverting enzyme inhibitors, α and βblockers, calcium channel blockers, diuretics, monoamine oxidase inhibitors, tricyclic antidepressants and phenothiazines. Any such drugs should be stopped first. Once the diagnosis is confirmed aggravating factors such as dehydration, extreme heat and excess consumption of alcohol should be avoided.

Box 2 Symptoms of orthostatic intolerance

  • Headache
  • Fatigue
  • Sleep disorder
  • Weakness
  • Hyperventilation/dyspnoea
  • Tremulousness
  • Sweating
  • Anxiety/palpitation
  • Dizziness/vertigo
  • Presyncope/syncope

Nonpharmacological measures

Patients should be advised to take aerobic exercise on a regular basis so that venous return from the lower extremities can be increased. Patients with dysautonomic syncope can be advised to wear graded compressive hosiery extending up to the waist, thus helping to increase static pressure at the calf and decrease venous pooling. A high fluid intake should be encouraged with at least 3–5 g of common salt.

Pharmacotherapy

There is no specific drug treatment for POTS and it depends on the type of aetiology responsible for the syndrome.

Fludrocortisone has been tried with success. It helps by increasing sodium and fluid retention as well as by sensitising αadrenergic receptors. There are volumeexpanding agents like vasopressin, and vasoconstriction drugs like midodrine, which can be gradually titrated upward until the maximum dose is reached. Midodrine is an α1 receptor stimulating agent which helps to improve orthostatic tolerance. Methylphenidate, a long acting αagonist, also has been found to be effective. Erythropoietin, which helps in volume expansion as well having a direct vasoconstrictive effect, is worth trying in patients who are refractory to other treatment. The major disadvantages of using erythropoietin are that it is expensive and has to be given subcutaneously.

The hyperadrenergic form of POTS can be treated by βblocking agents or drugs like labetalol, which have both α and βreceptor blocking effects. In selected patient’s drugs such as clonidine can be used which act as sympatholytic agents.

It is suggested that the disturbances in central serotonin production and regulation affects the blood pressure and heart rate. Selective serotonin reuptake inhibitors (SSRIs) increase nerve communication and stimulation of the standing vasoconstriction reflex. This reduces venous blood pooling and increases orthostatic tolerance. This effect is beneficial in controlling the symptoms in patients with POTS. SSRIs have been used in the past for the treatment of neurally mediated hypotension and syncope. In symptomatic patients with POTS, the addition of an SSRI or a norepinephrine reuptake inhibitor (NRI) would be beneficial. An NRI is more beneficial in patients with POTS. Bupropion can be used and gradually titrated upward.

Combination of drugs such as SSRI and NRI (venlafaxine and duloxetine) are also effective in treating selected patient with POTS. Patients are able to tolerate these agents with minimal side effects. Sometimes the combination of an SSRI with bupropion can be also used.

Box 3 Signs to look for in suspected orthostatic intolerance

  • Pallor
  • Tachycardia
  • Hypoxia
  • Postural hypotension
  • Arrhythmia
  • Focal neurological deficit

Box 4 Investigations in a case of suspected orthostatic intolerance

  • Blood: FBC, glucose levels, electrolytes, thyroid function tests, bone profile, serum cortisol
  • ECG
  • Cervical spine x ray
  • Catecholamine levels (blood and urine)
  • 70° head tilt table test
  • EEG
  • Brain CT scan
  • Sweat test
  • Sudomotor function test

CT, computed tomography; ECG, electrocardiogram; EEG, electroencephalogram; FBC, full blood count.

Pyridostigmine, an acetylcholine esterase inhibitor, has shown promising results in the management of POTS caused by postviral infection and autoimmune disorders. Low dose combination therapy is better than high dose monotherapy.

As patients' activities of daily living can become so compromised that they require help in all aspects, a multidisciplinary approach to their treatment is required. It is essential to involve social workers, occupational therapists and clinical psychologists as well as legal counsellors.

PROGNOSIS

Prognosis depends on aetiology. Patients may have continuous symptoms. They may be unable to cope with their employment or normal daily activities. After postviral episodes around 50% of patients recover in 2–5 years. Prognosis is good in adolescent patients. In the majority >90% respond to a combination of physical methods as well as pharmacotherapy. In the hyperadrenergic state patients will require lifelong treatment. In the secondary form the causative disorder has to be treated in order for patients to become symptomfree.

CONCLUSION

POTS is a heterogeneous disorder that disturbs normal autonomic control. This is a wellknown disease entity which is under diagnosed and also underestimated. It is under diagnosed because symptoms mimic vasovagal syndrome. However, it is being diagnosed more and more by tilt table study or at syncope assessment clinics. Finally, treatment is dependent upon identifying the subtype and then pursuing a comprehensive management plan.

Abbreviations

CDC - US Centers for Disease Control and Prevention

CFS - chronic fatigue syndrome

ME - myalgic encephalomyelitis

NMH - neurally mediated hypotension

NRI - norepinephrine reuptake inhibitor

POTS - postural orthostatic tachycardia syndrome

SSRI - selective serotonin reuptake inhibitor

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600095/

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Many of the times, parents ask, " What is the difference between an IEP and Sec. 504?". It is a very good question and commonly a confusing choice for schools. The most binding and extensive plan is an IEP which offers the fastest method to enforcement. Section 504 plans cannot alter the access to the general education curriculum where an IEP can. Just because your student is an A student with a disability does not mean that they do not qualify for an IEP. No student can have both plans active at the same time. To learn more please click here to review the simple guide we have created for parents.

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A hot topic in the Ehlers-Danlos Syndrome community lately is the discussion revolving around truancy. One way to protect yourself from this allegation is to have an Individual Health Plan (IHP) in place for your child. In this plan, you will want wording to the effect that states the student will possibly have frequent absences do to their health issues and medical appointments. The IHP also helps the school staff develop an appreciation for your child's medical needs as it is shared with all who comes in contact with them. To review this guide feel free to click here and share it with others.

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Non-compliance of an IEP or Section 504 plan is never easy on the parents, but worse, the impact it has on a student is horrible. The faster a compliance issue is addressed and resolved, the better it is for the student's ability to achieve a Free Appropriate Public Education (FAPE). Compliance issues can be highly emotional at times, which can lead to other unwanted problems, always try to remain calm and professional. CEDSA staff members are very versed in helping families obtain proper compliance with the student's best interest in mind always, if you need help feel free to contact us. We built a guide to help parents who choose to self advocate or who would like to know more about the compliance process. To view this guide please click here